primary lateral sclerosis การใช้

• Mutations in the ALS2 gene, found on Chromosome 2, are responsible for causing Juvenile Primary Lateral Sclerosis.
• She died on February 10, 2009, at her Manhattan home after a battle with primary lateral sclerosis.
• "It can be a pain, " said Luigart, who has a rare neuromuscular disorder called Primary Lateral Sclerosis.
• Primary lateral sclerosis ( PLS ) usually presents with gradual-onset, progressive, lower-extremity stiffness and pain due to muscle spasticity.
• Juvenile Primary Lateral Sclerosis has an autosomal recessive pattern of inheritance, meaning both copies of the gene in each cell are altered.
• A variety of conditions have similar symptoms to SPS, including myelopathies, dystonias, spinocerebellar degenerations, primary lateral sclerosis, neuromyotonia, and some psychogenic disorders.
• Juvenile Primary Lateral Sclerosis is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered.
• It is currently unknown how the loss of functional alsin protein causes the death of motor neurons and the symptoms of juvenile primary lateral sclerosis.
• PLS is not considered hereditary when onset is in adulthood; however, juvenile primary lateral sclerosis ( JPLS ) has been linked to a mutation in the ALS2 gene which encodes the cell-signalling protein alsin.
• They include amyotrophic lateral sclerosis ( ALS ), primary lateral sclerosis ( PLS ), progressive muscular atrophy ( PMA ), progressive bulbar palsy ( PBP ) and pseudobulbar palsy; spinal muscular atrophies are also sometimes included in the group.
• "' Juvenile primary lateral sclerosis "'( "'JPLS "') ", also known as primary lateral sclerois ( PLSJ ), " is a rare genetic disorder, with a small number of reported cases, characterized by progressive weakness and stiffness of muscles in the arms, legs, and face.